JWH-018 (1-pentyl-3-(1-naphthoyl)indole) or AM-678 is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors.
with some selectivity for CB2.
It produces effects in animals similar to those of tetrahydrocannabinol (THC).
This is to say, As a full agonist at both the CB1 and CB2 cannabinoid receptors, this chemical compound is classified as an analgesic medication.
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These compounds work by mimicking the body’s naturally-produced endocannabinoid hormones .
2-AG and anandamide (AEA), which are biologically active and can exacerbate or inhibit nerve signaling.
In short, As the cause is poorly understood in chronic pain states, more research and development should be done before we can realize the therapeutic potential of this class of biologic compounds.