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What is 4-MEC?

4MEC is an abbreviation of 4-Methylethcathinone and is chemically similar to methcathinone. It is a synthetic substance and is considered to be stimulant and enactogen drug of the amphetamine, phenethylamine and cathinone class.

4 MEC is chemically a substituted cathinone where the cathinones are the sub-class of amphetamines. It consists of the same core amphetamine skeleton whereas it undergoes methyl substitution at R4 position and ethyl group substitution at RN position.

It is being marketed as a single substance or in combination of other substituted cathinones commonly known as “NRG-2”, and also “NRG-1”.

It has been sold in replacement to mephedrone (4-mmc) after it was banned. It can be purchased online, as it has become available in 2010. In 2011, it has become more commonly available as a powder form, or in powder products in which the active component isn’t mentioned, and used in some “NRG-2” samples, although their tablet form is also reported.

There are some reports that support the speculation that it has been used as an active ingredient in fake “Ecstasy” pills in countries, such as Newzealand.

It has been found that it is less likely to cause physical addiction, so withdrawal symptoms are not life threatening and minimal in severity. But consumers have reported psychological addiction to this drug.

Bioactivity of 4-MEC

It possesses a psychoactive effect. A little have been known about the pharmacological activity of 4 MEC, as the data of human use is not extensively available. The activity of substituted cathinone class of enactogenic and stimulant drugs exerts their action by acting as a dopamine re-uptake inhibitor.

The agonistic effect on this receptor set is responsible for an increased rate of firing of post – synaptic neurons, and triggers both the cognitive and physical stimulation within the individual.

Expected Physical effects of 4-methylethcathinone

It causes mental and physical stimulation, euphoria, mood lift, empathetic feeling, and increase in sociability, desire to talk with others, relaxed and pleasurable rushing, and increased appreciation of music.

As with other psychoactive drugs, it also causes altered consciousness state, appetite suppression, pupil dilation, unusual body sensations (chills, energy, facial flushing), change in body temperature regulation, increase in heart rate and blood pressure, tremor, nystagmus.

There are some reports that indicate its potential of initiating compulsive redosing, sweating, heart palpitations, impaired short term memory, insomnia, trismus (tightened jaw muscles) and bruxia, muscle twitching, dizziness, light headedness, vertigo.

When it is taken as insufflations, pain and swelling in nose and throat may occur, and can also cause sinusitis, bleeding from nose etc.

Dosage Information for 4-methyl-N-ethylcathinone

The oral dosage starts from a threshold of 15 – 50 mg. For mild stimulant effects, the dose can be given from 50 – 100 mg. The commonly used dosage concentration is 100 – 200 mg. A strong effect is observed on oral administration above 150 – 300 mg dose.

In insufflations (snorting), the threshold effect is seen with 5 – 25 mg and light effects at 25 – 40 mg dose. Its common dose ranges from 40 – 100 mg while stronger effect can be obtained at dosage of 100 – 200 mg. This dosage information should not be taken as recommendation.

The oral dosage total duration of action is from 2 – 5 hours, with its onset of action starting within 15 – 45 minutes, coming up at 15 – 30 minutes and pleateau at 15 – 30 minutes, and finally coming down at 30 – 90 minutes. The after effects are from 2 – 4 hours.

For insufflations, the total duration of action is from 2 – 3 hours, and onset showing within 5 minutes, coming up at 5 – 10 minutes, pleateau at 10 – 60 minutes and coming down at 45 – 90 minutes. The after affects are from 2 – 4 hours.

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